Across TCGA pan-cancer cohorts, SPATA42 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SPATA42’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SPATA42 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPATA42 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
HNSC, KICH, and COAD are the cancer types where SPATA42 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPATA42 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.