Across TCGA patient cohorts, SPATA41 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA41-associated genes across cancer lineages are HSPE1-MOB4, MIR4727, and F8A2. Each is linked with SPATA41 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA41-to-partner and partner-to-SPATA41 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA41→partner) and Y-score (partner→SPATA41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPE1-MOB4 →	+0.197	+3.799	.004	.003	3	1
UCEC	MIR4727 →	+0.330	+3.551	.008	.004	3	1
UCEC	F8A2 →	+0.040	+3.694	<.001	.003	3	1
UCEC	C7orf77 →	+0.120	+2.812	<.001	.008	3	1
UCEC	IGHV4-4 →	+1.427	+2.758	<.001	.008	3	1
UCEC	IGKV1OR-2 →	+0.277	+2.715	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration

SPATA41 survival (RNA) · tumor vs normal (RNA) · all SPATA41 data types