SPATA4

Across TCGA cell cohorts, SPATA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,551 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPATA4-associated GO terms across cancer lineages are Macroautophagy, Endoplasmic reticulum to Golgi vesicle-mediated transport, and Cellular response to nitrogen starvation. Each is linked with SPATA4 in more than 8 cancer types. Because this analysis shows association rather than direction, both SPATA4-to-partner and partner-to-SPATA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macroautophagy grouped by SPATA4-low versus SPATA4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA4→partner) and Y-score (partner→SPATA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.049	+0.150	<.001	.003	3	9
BONE	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.076	+0.280	<.001	.006	3	8
LUNG_NSCLC_LUAD	Cellular response to nitrogen starvation →	+0.110	+0.181	<.001	.009	3	7
BONE	Negative regulation of calcineurin-mediated signaling →	+0.268	+0.337	.002	.001	3	7
CNS	Autophagosome organization →	+0.042	+0.335	<.001	<.001	2	8
LUNG_NSCLC_LUAD	Positive regulation of protein modification by small protein conjugation or removal →	+0.044	+0.201	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,551 associations by consensus.

Macroautophagy by SPATA4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →