SPATA31C2

Across TCGA patient cohorts, SPATA31C2 mutation is significantly associated with the RNA expression of many other genes, with 1,727 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA31C2-associated genes across cancer lineages are SAC3D1, NDUFA8, and TSPAN7. Each is linked with SPATA31C2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPATA31C2-to-partner and partner-to-SPATA31C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAC3D1 grouped by SPATA31C2-low versus SPATA31C2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA31C2→partner) and Y-score (partner→SPATA31C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAC3D1 →	+0.515	+2.353	<.001	<.001	3	4
UCEC	NDUFA8 →	+0.344	+2.111	<.001	.003	3	4
UCEC	TSPAN7 →	-1.142	-1.989	<.001	.001	3	3
UCEC	CCNB2 →	+0.581	+1.716	.002	.004	3	3
UCEC	SLC27A4 →	+0.482	+2.409	<.001	<.001	3	3
UCEC	SSNA1 →	+0.328	+2.753	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,727 associations by consensus.

SAC3D1 by SPATA31C2 expression — UCEC

Explore this box plot interactively →