SPATA31C2

Across TCGA patient cohorts, SPATA31C2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA31C2-associated genes across cancer lineages are eIF4E, MYH11, and Acetyl-a-Tubulin-Lys40. Each is linked with SPATA31C2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA31C2-to-partner and partner-to-SPATA31C2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by SPATA31C2-low versus SPATA31C2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA31C2→partner) and Y-score (partner→SPATA31C2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	eIF4E →	+0.110	+2.473	.036	.010	3	2
LUSC	MYH11 →	-0.726	-3.000	.026	.033	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.514	+2.009	.004	.005	3	2
UCEC	INPP4B →	-0.256	-2.222	.028	.009	3	2
UCEC	Akt_pT308 →	+0.517	+2.000	.022	.029	3	2
UCEC	PCNA →	+0.244	+2.115	.001	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eIF4E by SPATA31C2 expression — LUSC

Explore this box plot interactively →