SPATA31C1

Across TCGA patient cohorts, SPATA31C1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA31C1-associated genes across cancer lineages are Cyclin-E2, ATM, and 4E-BP1. Each is linked with SPATA31C1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPATA31C1-to-partner and partner-to-SPATA31C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by SPATA31C1-low versus SPATA31C1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA31C1→partner) and Y-score (partner→SPATA31C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Cyclin-E2 →	+0.142	+1.883	.008	.031	3	3
UCEC	ATM →	-0.468	-3.571	.002	.002	3	3
UCEC	4E-BP1 →	+0.316	+3.807	<.001	<.001	3	3
LUSC	RBM15 →	+0.339	+1.883	.023	.031	3	2
LUSC	Cyclin-B1 →	+0.474	+3.321	.011	.009	3	2
UCEC	INPP4B →	-0.236	-1.678	.032	.021	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Cyclin-E2 by SPATA31C1 expression — LUSC

Explore this box plot interactively →