SPATA31A3

Across TCGA patient cohorts, SPATA31A3 mutation is significantly associated with the RNA expression of many other genes, with 1,277 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA31A3-associated genes across cancer lineages are RNY4P16, FCER1A, and CDCA2. Each is linked with SPATA31A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA31A3-to-partner and partner-to-SPATA31A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNY4P16 grouped by SPATA31A3-low versus SPATA31A3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA31A3→partner) and Y-score (partner→SPATA31A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNY4P16 →	+0.489	+5.203	<.001	.007	3	2
UCEC	FCER1A →	-0.691	-2.638	.001	<.001	3	2
UCEC	CDCA2 →	+0.627	+1.781	.002	.008	3	2
UCEC	ZNRF1 →	+0.533	+2.158	<.001	<.001	3	2
UCEC	TMEM244 →	+0.153	+1.541	<.001	.006	3	2
UCEC	TRPC7-AS1 →	+0.188	+1.463	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,277 associations by consensus.

RNY4P16 by SPATA31A3 expression — BRCA

Explore this box plot interactively →