SPATA31A3

Across TCGA patient cohorts, SPATA31A3 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA31A3-associated genes across cancer lineages are mTOR_pS2448, eEF2, and mTOR. Each is linked with SPATA31A3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPATA31A3-to-partner and partner-to-SPATA31A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SPATA31A3-low versus SPATA31A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA31A3→partner) and Y-score (partner→SPATA31A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.154	-2.687	.005	.005	3	3
UCEC	eEF2 →	+0.286	+3.169	.029	.018	3	2
UCEC	mTOR →	-0.173	-1.502	.003	.030	3	2
UCEC	Src_pY527 →	-0.415	-1.896	.008	.015	3	2
UCEC	TFRC →	+0.392	+1.847	.044	.008	3	2
UCEC	ATM →	-0.475	-1.502	.004	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

mTOR_pS2448 by SPATA31A3 expression — UCEC

Explore this box plot interactively →