SPATA22

Across TCGA patient cohorts, SPATA22 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,845 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SPATA22-associated GO terms across cancer lineages are Endothelium development, Regulation of chemotaxis, and Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage. Each is linked with SPATA22 in more than 15 cancer types. Because this analysis shows association rather than direction, both SPATA22-to-partner and partner-to-SPATA22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endothelium development grouped by SPATA22-low versus SPATA22-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA22→partner) and Y-score (partner→SPATA22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Endothelium development →	+0.089	+0.165	<.001	<.001	3	16
ESCA	Regulation of chemotaxis →	+0.080	+0.156	<.001	<.001	2	16
ESCA	Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage →	+0.107	+0.157	<.001	<.001	3	15
ESCA	Substrate-dependent cell migration →	+0.099	+0.156	<.001	<.001	3	15
ESCA	Heart valve morphogenesis →	+0.089	+0.157	<.001	.001	2	16
ESCA	Semi-lunar valve development →	+0.091	+0.146	<.001	.001	2	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,845 associations by consensus.

Endothelium development by SPATA22 expression — ESCA

Explore this box plot interactively →