SPATA22

Across TCGA patient cohorts, SPATA22 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA22-associated genes across cancer lineages are eEF2, IRS1, and Myosin-IIa_pS1943. Each is linked with SPATA22 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA22-to-partner and partner-to-SPATA22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SPATA22-low versus SPATA22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA22→partner) and Y-score (partner→SPATA22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.278	+2.999	.047	.035	3	1
UCEC	IRS1 →	+0.213	+1.584	.008	.036	3	1
UCEC	Myosin-IIa_pS1943 →	+0.165	+2.115	.041	.017	3	1
UCEC	Notch1 →	+0.181	+3.469	.001	.002	3	1
UCEC	p62 Lck ligand →	+0.354	+2.469	.005	.010	3	1
UCEC	Paxillin →	+0.204	+1.594	.045	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

eEF2 by SPATA22 expression — UCEC

Explore this box plot interactively →