SPATA22

Across TCGA cell cohorts, SPATA22 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPATA22-associated genes across cancer lineages are C6orf118, DEFA4, and OR6Q1. Each is linked with SPATA22 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA22-to-partner and partner-to-SPATA22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by SPATA22-low versus SPATA22-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA22→partner) and Y-score (partner→SPATA22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.173	+4.115	<.001	.001	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	OR6Q1 →	+0.015	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

C6orf118 by SPATA22 expression — LARGE_INTESTINE

Explore this box plot interactively →