Across TCGA patient cohorts, SPATA21 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA21-associated genes across cancer lineages are Caspase-8, 14-3-3_beta, and Notch1. Each is linked with SPATA21 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA21-to-partner and partner-to-SPATA21 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA21→partner) and Y-score (partner→SPATA21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.282	-2.295	.012	.033	3	2
UCEC	14-3-3_beta →	-0.098	-2.973	.031	.035	3	1
UCEC	Notch1 →	+0.173	+2.000	.006	.032	3	1
UCEC	p62 Lck ligand →	+0.583	+3.469	<.001	.002	3	1
UCEC	PR →	-0.224	-3.169	.047	.019	3	1
UCEC	Tuberin →	+0.316	+2.000	.009	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

SPATA21 survival (RNA) · tumor vs normal (RNA) · all SPATA21 data types