SPATA20

Across TCGA patient cohorts, SPATA20 mutation is significantly associated with the RNA expression of many other genes, with 3,253 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA20-associated genes across cancer lineages are MIR1183, GRSF1, and SLC30A7. Each is linked with SPATA20 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPATA20-to-partner and partner-to-SPATA20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1183 grouped by SPATA20-low versus SPATA20-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA20→partner) and Y-score (partner→SPATA20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR1183 →	+0.253	+5.317	<.001	.002	3	3
SKCM	GRSF1 →	+0.442	+2.279	.003	.001	3	3
SKCM	SLC30A7 →	+0.548	+2.846	.003	.001	3	3
SKCM	THRAP3 →	+0.347	+3.729	.005	<.001	3	3
SKCM	TIPIN →	+0.397	+3.509	.009	.002	3	3
UCEC	TXLNA →	+0.457	+2.617	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,253 associations by consensus.

MIR1183 by SPATA20 expression — LIHC

Explore this box plot interactively →