SPATA20

Across TCGA patient cohorts, SPATA20 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA20-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_epsilon, and Annexin-1. Each is linked with SPATA20 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPATA20-to-partner and partner-to-SPATA20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SPATA20-low versus SPATA20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA20→partner) and Y-score (partner→SPATA20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.636	+2.019	.005	.017	3	3
COAD	14-3-3_epsilon →	+0.170	+2.849	.016	.034	3	2
UCEC	Annexin-1 →	+0.617	+3.479	.002	.002	3	2
COAD	Stathmin →	+0.274	+2.815	.001	.036	3	2
UCEC	eIF4E →	+0.160	+3.013	.048	.018	3	2
UCEC	ERK2 →	+0.250	+3.584	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Caspase-7-cleavedD198 by SPATA20 expression — UCEC

Explore this box plot interactively →