SPATA20

Across TCGA cell cohorts, SPATA20 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPATA20-associated genes across cancer lineages are LRIT1, DEFB108B, and PRR30. Each is linked with SPATA20 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA20-to-partner and partner-to-SPATA20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRIT1 grouped by SPATA20-low versus SPATA20-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA20→partner) and Y-score (partner→SPATA20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LRIT1 →	+0.027	+3.684	<.001	.004	3	1
BLOOD_Leukemia	DEFB108B →	+0.105	+3.684	<.001	.004	3	1
BLOOD_Leukemia	PRR30 →	+0.017	+3.684	<.001	.004	3	1
BLOOD_Leukemia	GUCA2A →	+0.026	+3.969	<.001	.009	3	1
BLOOD_Leukemia	DPRX →	+0.110	+3.475	<.001	.006	3	1
BLOOD_Leukemia	GAGE10 →	+0.103	+3.450	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

LRIT1 by SPATA20 expression — BLOOD_Leukemia

Explore this box plot interactively →