SPATA2

Across TCGA patient cohorts, SPATA2 mutation is significantly associated with the RNA expression of many other genes, with 3,704 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA2-associated genes across cancer lineages are MTND4P33, RNU5E-8P, and MTATP6P14. Each is linked with SPATA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA2-to-partner and partner-to-SPATA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND4P33 grouped by SPATA2-low versus SPATA2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA2→partner) and Y-score (partner→SPATA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MTND4P33 →	+0.047	+4.899	<.001	.005	3	2
SKCM	RNU5E-8P →	+0.544	+3.086	<.001	.001	3	2
COAD	MTATP6P14 →	+0.401	+4.821	<.001	.003	3	2
COAD	RN7SL607P →	+0.262	+3.797	.007	.003	3	2
SKCM	RPS20P20 →	+0.073	+3.132	.003	.003	3	2
LUSC	RN7SL135P →	+0.082	+4.578	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,704 associations by consensus.

MTND4P33 by SPATA2 expression — BLCA

Explore this box plot interactively →