SPATA2

Across TCGA patient cohorts, SPATA2 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA2-associated genes across cancer lineages are FoxM1, TIGAR, and ATM. Each is linked with SPATA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA2-to-partner and partner-to-SPATA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SPATA2-low versus SPATA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA2→partner) and Y-score (partner→SPATA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.191	+1.594	.040	.042	3	2
UCEC	TIGAR →	+0.124	+2.348	.023	<.001	3	2
UCEC	ATM →	-0.669	-3.893	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.669	+2.135	.001	.010	3	2
UCEC	14-3-3_beta →	-0.096	-1.673	.007	.040	3	1
UCEC	eEF2 →	+0.337	+2.321	.008	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

FoxM1 by SPATA2 expression — UCEC

Explore this box plot interactively →