SPATA2

Across TCGA cell cohorts, SPATA2 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPATA2-associated genes across cancer lineages are SPINT4, HIGD1C, and SPATA31D3. Each is linked with SPATA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA2-to-partner and partner-to-SPATA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPINT4 grouped by SPATA2-low versus SPATA2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA2→partner) and Y-score (partner→SPATA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPINT4 →	+0.047	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	HIGD1C →	+0.084	+5.662	<.001	.002	3	1
BREAST	SPATA31D3 →	+0.023	+5.169	<.001	.005	3	1
BLOOD_Leukemia	CALHM4 →	+0.030	+4.269	<.001	.002	3	1
BLOOD_Leukemia	PPP1R42 →	+0.139	+4.133	<.001	.003	3	1
BLOOD_Leukemia	UCN3 →	+0.020	+3.855	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SPINT4 by SPATA2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →