SPATA19

Across TCGA patient cohorts, SPATA19 mutation is significantly associated with the RNA expression of many other genes, with 588 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA19-associated genes across cancer lineages are RNU7-113P, BTBD10, and SHCBP1. Each is linked with SPATA19 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPATA19-to-partner and partner-to-SPATA19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-113P grouped by SPATA19-low versus SPATA19-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA19→partner) and Y-score (partner→SPATA19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU7-113P →	+0.620	+3.490	.003	.005	3	3
UCEC	BTBD10 →	+0.576	+3.202	.007	.009	3	2
UCEC	SHCBP1 →	+0.819	+3.343	.002	.005	3	2
HNSC	MIR3139 →	+0.902	+5.063	<.001	.001	3	2
HNSC	LINC01906 →	+0.148	+5.763	<.001	.001	3	2
LUAD	ACTL7A →	+0.057	+3.293	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 588 associations by consensus.

RNU7-113P by SPATA19 expression — LUAD

Explore this box plot interactively →