SPATA19

Across TCGA patient cohorts, SPATA19 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA19-associated genes across cancer lineages are p27_pT198, Bcl-2, and Caspase-7-cleavedD198. Each is linked with SPATA19 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPATA19-to-partner and partner-to-SPATA19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by SPATA19-low versus SPATA19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA19→partner) and Y-score (partner→SPATA19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.167	+3.169	.004	.020	3	1
UCEC	Bcl-2 →	-0.488	-3.143	.010	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.949	+3.169	.003	.020	1	3
UCEC	S6_pS235_S236 →	+0.594	+3.169	.012	.020	2	1
UCEC	S6_pS240_S244 →	+0.797	+3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p27_pT198 by SPATA19 expression — UCEC

Explore this box plot interactively →