SPATA18

Across TCGA patient cohorts, SPATA18 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA18-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and eIF4E. Each is linked with SPATA18 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPATA18-to-partner and partner-to-SPATA18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SPATA18-low versus SPATA18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA18→partner) and Y-score (partner→SPATA18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.791	+2.522	<.001	<.001	3	3
UCEC	EGFR_pY1068 →	-0.195	-1.807	.022	.004	3	2
UCEC	eIF4E →	+0.168	+3.183	.019	.009	3	2
UCEC	PCNA →	+0.206	+1.514	.005	.015	3	2
UCEC	PDCD4 →	-0.458	-1.514	.004	.015	3	2
UCEC	Annexin-1 →	+0.548	+2.700	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Caspase-7-cleavedD198 by SPATA18 expression — UCEC

Explore this box plot interactively →