SPATA18

Across TCGA cell cohorts, SPATA18 mutation is significantly associated with the mutation status of many other genes, with 3,000 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPATA18-associated genes across cancer lineages are KCNC4, TYSND1, and DAAM2. Each is linked with SPATA18 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPATA18-to-partner and partner-to-SPATA18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNC4 grouped by SPATA18-low versus SPATA18-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA18→partner) and Y-score (partner→SPATA18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KCNC4 →	+4.430	+3.823	.001	.001	1	4
LUNG_NSCLC_LUAD	TYSND1 →	+5.000	+4.187	.008	.008	1	4
OVARY	DAAM2 →	+3.240	+4.467	.004	.004	1	4
OVARY	ADAMTS13 →	+3.562	+4.684	.002	.002	1	4
OVARY	NYAP2 →	+5.562	+5.562	<.001	<.001	1	4
OVARY	CNTN2 →	+4.977	+4.415	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,000 associations by consensus.

KCNC4 by SPATA18 expression — BLOOD_Leukemia

Explore this box plot interactively →