SPATA18

Across TCGA cell cohorts, SPATA18 mutation is significantly associated with the drug of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPATA18-associated genes across cancer lineages are AZD5153, Mirin, and GSK1904529A. Each is linked with SPATA18 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA18-to-partner and partner-to-SPATA18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZD5153 grouped by SPATA18-low versus SPATA18-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA18→partner) and Y-score (partner→SPATA18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AZD5153 →	+0.537	+2.649	.033	.046	3	2
LARGE_INTESTINE	Mirin →	+0.449	+2.646	.017	.047	3	1
LARGE_INTESTINE	GSK1904529A →	+0.522	+2.678	.001	.037	3	1
LARGE_INTESTINE	150412 →	+0.398	+2.777	.017	.038	3	1
LARGE_INTESTINE	CDK9_5576 →	+0.532	+2.649	.042	.046	2	1
LARGE_INTESTINE	JAK1_8709 →	+0.459	+2.649	.020	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

AZD5153 by SPATA18 expression — LARGE_INTESTINE

Explore this box plot interactively →