SPATA16

Across TCGA patient cohorts, SPATA16 mutation is significantly associated with the RNA expression of many other genes, with 3,093 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA16-associated genes across cancer lineages are NDUFAF5, CCNB2, and DONSON. Each is linked with SPATA16 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPATA16-to-partner and partner-to-SPATA16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFAF5 grouped by SPATA16-low versus SPATA16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA16→partner) and Y-score (partner→SPATA16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFAF5 →	+0.373	+2.534	<.001	<.001	3	4
UCEC	CCNB2 →	+0.593	+2.459	.004	<.001	3	3
UCEC	DONSON →	+0.521	+3.732	<.001	<.001	3	3
UCEC	PKN3 →	+0.661	+2.081	<.001	.001	3	3
UCEC	SLBP →	+0.703	+2.949	<.001	<.001	3	3
UCEC	C1QBP →	+0.560	+3.043	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,093 associations by consensus.

NDUFAF5 by SPATA16 expression — UCEC

Explore this box plot interactively →