SPATA16

Across TCGA cell cohorts, SPATA16 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible SPATA16-associated genes across cancer lineages are PLVAP, CCDC182, and PIP. Each is linked with SPATA16 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA16-to-partner and partner-to-SPATA16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLVAP grouped by SPATA16-low versus SPATA16-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA16→partner) and Y-score (partner→SPATA16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLVAP →	+0.254	+3.539	<.001	.004	3	2
OVARY	CCDC182 →	+0.076	+4.700	<.001	.002	3	2
BLOOD_Myeloma	PIP →	+0.040	+4.807	<.001	.006	3	1
OESOPHAGUS	GHRH →	+0.060	+4.906	<.001	.006	3	1
OESOPHAGUS	BMP15 →	+0.030	+4.906	<.001	.006	3	1
OESOPHAGUS	KRTAP1-4 →	+0.143	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

PLVAP by SPATA16 expression — LARGE_INTESTINE

Explore this box plot interactively →