SPATA13

Across TCGA patient cohorts, SPATA13 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA13-associated genes across cancer lineages are Lck, ETS-1, and FOXO3a_pS318_S321. Each is linked with SPATA13 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPATA13-to-partner and partner-to-SPATA13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by SPATA13-low versus SPATA13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA13→partner) and Y-score (partner→SPATA13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.183	+1.700	.004	.042	3	3
UCEC	ETS-1 →	+0.238	+2.222	.019	.009	3	2
UCEC	FOXO3a_pS318_S321 →	-0.097	-1.575	.014	.017	3	2
UCEC	Chk1_pS345 →	-0.101	-2.000	.022	.009	3	2
COAD	ACC_pS79 →	-0.364	-3.313	.009	.010	3	1
UCEC	14-3-3_beta →	-0.079	-2.088	.014	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Lck by SPATA13 expression — UCEC

Explore this box plot interactively →