SPAST

Across TCGA patient cohorts, SPAST protein abundance is significantly associated with the RNA expression of many other genes, with 20,493 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPAST-associated genes across cancer lineages are GTF3C2, CENPF, and KIF14. Each is linked with SPAST in more than 6 cancer types. Because this analysis shows association rather than direction, both SPAST-to-partner and partner-to-SPAST results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPAST versus GTF3C2 in HNSC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAST→partner) and Y-score (partner→SPAST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GTF3C2 →	+0.618	+0.475	<.001	<.001	3	7
LSCC	CENPF →	+1.028	+0.500	<.001	<.001	3	7
BRCA	KIF14 →	+0.738	+0.196	<.001	<.001	3	7
LSCC	IGF2BP3 →	+1.585	+0.380	<.001	<.001	3	7
LSCC	SELENOI →	+0.892	+0.498	<.001	<.001	3	7
HNSC	CENPO →	+0.726	+0.476	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,493 associations by consensus.

SPAST vs GTF3C2 — HNSC

Explore this scatter interactively →