SPAST

Across TCGA patient cohorts, SPAST mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPAST-associated genes across cancer lineages are ASNS, Notch1, and Caspase-7-cleavedD198. Each is linked with SPAST in more than 3 cancer types. Because this analysis shows association rather than direction, both SPAST-to-partner and partner-to-SPAST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SPAST-low versus SPAST-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAST→partner) and Y-score (partner→SPAST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.458	+1.700	<.001	.042	3	4
UCEC	Notch1 →	+0.158	+3.183	.003	.009	3	3
UCEC	Caspase-7-cleavedD198 →	+0.515	+1.894	.023	.030	3	3
UCEC	Di-Ras3 →	-0.169	-2.584	.002	.001	3	3
UCEC	EGFR_pY1068 →	-0.273	-2.807	.004	.003	3	2
UCEC	Shc_pY317 →	-0.166	-2.087	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

ASNS by SPAST expression — UCEC

Explore this box plot interactively →