SPAST

Across TCGA cell cohorts, SPAST RNA expression is significantly associated with the go_rna of many other GO terms, with 5,083 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPAST-associated GO terms across cancer lineages are Positive regulation of microtubule depolymerization, Regulation of centrosome duplication, and Transport along microtubule. Each is linked with SPAST in more than 15 cancer types. Because this analysis shows association rather than direction, both SPAST-to-partner and partner-to-SPAST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of microtubule depolymerization grouped by SPAST-low versus SPAST-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAST→partner) and Y-score (partner→SPAST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of microtubule depolymerization →	+0.207	+0.962	<.001	<.001	3	16
LUNG_SCLC	Regulation of centrosome duplication →	+0.078	+0.519	.006	.003	2	16
LUNG_SCLC	Transport along microtubule →	+0.060	+0.577	.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Nuclear pore organization →	+0.147	+1.070	<.001	<.001	3	15
LARGE_INTESTINE	Positive regulation of organelle assembly →	+0.059	+0.613	<.001	<.001	3	15
BLOOD_Myeloma	Exit from mitosis →	+0.100	+0.810	.001	.004	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,083 associations by consensus.

Positive regulation of microtubule depolymerization by SPAST expression — BONE

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