SPAST

Across TCGA cell cohorts, SPAST mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPAST-associated genes across cancer lineages are OR2F2, PNMA6F, and OR13C7. Each is linked with SPAST in more than 1 cancer types. Because this analysis shows association rather than direction, both SPAST-to-partner and partner-to-SPAST results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2F2 grouped by SPAST-low versus SPAST-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPAST→partner) and Y-score (partner→SPAST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2F2 →	+0.036	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	PNMA6F →	+0.006	+4.887	.009	.009	3	1
LUNG_NSCLC_LUAD	OR13C7 →	+0.049	+6.266	<.001	<.001	3	1
LARGE_INTESTINE	BAAT →	+0.420	+3.273	<.001	.006	3	1
LARGE_INTESTINE	MSGN1 →	+0.094	+3.345	<.001	.001	3	1
LARGE_INTESTINE	P2RY12 →	+0.119	+2.688	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

OR2F2 by SPAST expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →