SPART-AS1

Across TCGA pan-cancer cohorts, SPART-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SPART-AS1 data layer compared with 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SPART-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPART-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRP and LAML show a favorable association.

KIRC, COAD, and SKCM are the cancer types where SPART-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.554	0.693	<.001	50	view →
COAD	OS	Quartile	All	0.274	0.671	.003	47	view →
SKCM	OS	Quartile	II,III,IV	0.206	0.360	.003	38	view →
KIRP	DFS	Median	II,III,IV	0.873	0.352	.008	34	view →
LAML	DFS	Tertile	All	0.558	0.256	<.001	30	view →
CESC	OS	Tertile	All	0.879	0.723	.003	24	view →
STAD	OS	Tertile	II,III,IV	0.413	0.724	.010	23	view →
THYM	DFS	Tertile	All	1.000	0.591	.005	16	view →
LUSC	DFS	Quartile	All	0.855	0.603	.019	15	view →
BRCA	DFS	Tertile	All	0.632	0.435	.004	13	view →
MESO	OS	Median	III,IV	0.729	0.346	.016	12	view →
BLCA	OS	Quartile	All	0.827	0.669	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SPART-AS1–KIRC (DFS)

Open the KIRC breakdown →