SPARCL1

Across TCGA pan-cancer cohorts, SPARCL1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SPARCL1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SPARCL1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SPARCL1 is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

LUAD, COAD, and LSCC are the cancer types where SPARCL1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPARCL1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−1.286	<.001	9	view →
COAD	Male	All	−0.921	<.001	9	view →
LSCC	Male	II,III,IV	−1.278	<.001	8	view →
OV	All	All	−1.049	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SPARCL1–LUAD

Open the LUAD breakdown →