SPARCL1

Across TCGA patient cohorts, SPARCL1 RNA expression is significantly associated with the protein abundance of many other proteins, with 23,465 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SPARCL1-associated proteins across cancer lineages are SORBS1, SPARCL1_S295, and SEPTIN11. Each is linked with SPARCL1 in more than 9 cancer types. Because this analysis shows association rather than direction, both SPARCL1-to-partner and partner-to-SPARCL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPARCL1 versus SORBS1 in BRCA, with a Pearson correlation of 0.66.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPARCL1→partner) and Y-score (partner→SPARCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SORBS1 →	+0.797	+1.358	<.001	<.001	3	10
BRCA	SPARCL1_S295 →	+1.506	+1.566	<.001	<.001	3	10
BRCA	SEPTIN11 →	+0.446	+0.982	<.001	<.001	3	9
GBM	SEPTIN2 →	+0.280	+1.018	<.001	<.001	3	9
BRCA	KANK2 →	+0.692	+1.628	<.001	<.001	3	9
HNSC	KANK2_S540 →	+0.678	+1.254	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,465 associations by consensus.

SPARCL1 vs SORBS1 — BRCA

Explore this scatter interactively →