SPARCL1

Across TCGA patient cohorts, SPARCL1 mutation is significantly associated with the RNA expression of many other genes, with 1,450 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPARCL1-associated genes across cancer lineages are NEDD8-MDP1, ADNP2, and LRRC59. Each is linked with SPARCL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPARCL1-to-partner and partner-to-SPARCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEDD8-MDP1 grouped by SPARCL1-low versus SPARCL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPARCL1→partner) and Y-score (partner→SPARCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NEDD8-MDP1 →	+0.228	+2.670	<.001	<.001	3	3
UCEC	ADNP2 →	+0.544	+2.625	.003	.005	3	3
UCEC	LRRC59 →	+0.542	+3.743	.001	<.001	3	3
UCEC	UBR7 →	+0.607	+2.638	<.001	<.001	3	3
UCEC	EIF2S1 →	+0.525	+2.839	.002	.001	3	3
CESC	OR4K2 →	+0.041	+3.684	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,450 associations by consensus.

NEDD8-MDP1 by SPARCL1 expression — UCEC

Explore this box plot interactively →