SPARCL1

Across TCGA patient cohorts, SPARCL1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPARCL1-associated genes across cancer lineages are ATM, Rab25, and Caspase-7-cleavedD198. Each is linked with SPARCL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPARCL1-to-partner and partner-to-SPARCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SPARCL1-low versus SPARCL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPARCL1→partner) and Y-score (partner→SPARCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.358	-1.584	.044	.036	3	3
UCEC	Rab25 →	-0.268	-2.999	.040	.035	3	2
UCEC	Caspase-7-cleavedD198 →	+0.698	+1.827	.002	.015	3	2
UCEC	eIF4E →	+0.172	+3.169	.037	.019	2	2
UCEC	JNK2 →	+0.174	+1.584	.026	.036	3	1
UCEC	MEK1 →	+0.450	+2.115	.001	.017	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ATM by SPARCL1 expression — UCEC

Explore this box plot interactively →