SPARCL1

Across TCGA cell cohorts, SPARCL1 mutation is significantly associated with the drug of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPARCL1-associated genes across cancer lineages are CX-5461, BDF00022089a, and Sinularin. Each is linked with SPARCL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPARCL1-to-partner and partner-to-SPARCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CX-5461 grouped by SPARCL1-low versus SPARCL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPARCL1→partner) and Y-score (partner→SPARCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CX-5461 →	+0.644	+2.652	.029	.045	3	1
LARGE_INTESTINE	BDF00022089a →	+0.393	+2.649	.010	.046	2	1
LARGE_INTESTINE	Sinularin →	+0.520	+2.777	<.001	.038	2	1
LARGE_INTESTINE	Afatinib →	+0.587	+2.646	.042	.047	1	1
LARGE_INTESTINE	PCI-34051 →	+0.542	+2.646	.004	.047	1	1
LARGE_INTESTINE	JAK1_8709 →	+0.442	+2.649	.025	.046	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

CX-5461 by SPARCL1 expression — LARGE_INTESTINE

Explore this box plot interactively →