SPARC

Across TCGA pan-cancer cohorts, SPARC Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SPARC data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SPARC Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPARC expression acts as an unfavorable survival marker.

HNSC, BLCA, and SKCM are the cancer types where SPARC Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.152	0.768	<.001	48	view →
BLCA	OS	Median	All	0.214	0.620	.009	21	view →
SKCM	OS	Median	II,III,IV	0.245	0.731	.014	13	view →
LIHC	OS	Median	All	0.144	0.688	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SPARC–HNSC (OS)

Open the HNSC breakdown →