SPARC

Across TCGA patient cohorts, SPARC RNA expression is significantly associated with the protein abundance of many other proteins, with 22,186 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SPARC-associated proteins across cancer lineages are SERPINH1, SH3PXD2B, and SRPX2. Each is linked with SPARC in more than 9 cancer types. Because this analysis shows association rather than direction, both SPARC-to-partner and partner-to-SPARC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPARC versus SERPINH1 in OV, with a Pearson correlation of 0.66.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPARC→partner) and Y-score (partner→SPARC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPINH1 →	+0.696	+1.759	<.001	<.001	3	10
OV	SH3PXD2B →	+0.530	+1.683	<.001	<.001	3	10
BRCA	SRPX2 →	+1.016	+1.403	<.001	<.001	3	10
UCEC	SVIL →	+0.532	+0.751	<.001	<.001	3	10
UCEC	SVIL_S467 →	+0.876	+0.634	.003	.004	3	10
OV	COL12A1 →	+1.213	+1.833	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,186 associations by consensus.

SPARC vs SERPINH1 — OV

Explore this scatter interactively →