SPARC

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SPARC protein abundance is significantly associated with the RNA expression of many other genes, with 13,590 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible SPARC-associated genes across cancer lineages are MYL9, COL1A1, and LAMA4. Each is linked with SPARC in more than 8 cancer types. Because this analysis shows association rather than direction, both SPARC-to-partner and partner-to-SPARC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPARC versus MYL9 in OV, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPARC→partner) and Y-score (partner→SPARC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVMYL9 →+1.550+0.897<.001<.00139
OVCOL1A1 →+2.565+0.880<.001<.00139
OVLAMA4 →+1.196+0.980<.001<.00139
OVPDGFRB →+1.548+0.914<.001<.00139
BRCAPMEPA1 →+1.023+0.598<.001<.00139
OVCOL5A1 →+2.225+0.909<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 13,590 associations by consensus.

SPARC vs MYL9 — OV

Per-sample scatter of SPARC vs MYL9 in OV (Pearson r = 0.52).

Explore this scatter interactively →

Exploration