SPARC

Across TCGA patient cohorts, SPARC mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPARC-associated genes across cancer lineages are FoxM1, A-Raf_pS299, and Heregulin. Each is linked with SPARC in more than 1 cancer types. Because this analysis shows association rather than direction, both SPARC-to-partner and partner-to-SPARC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SPARC-low versus SPARC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPARC→partner) and Y-score (partner→SPARC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.194	+1.765	.046	.014	3	2
UCEC	A-Raf_pS299 →	-0.099	-3.321	.027	.010	3	1
UCEC	Heregulin →	-0.101	-2.446	.029	.018	3	1
UCEC	JNK2 →	+0.256	+1.765	<.001	.014	3	1
UCEC	MEK1 →	+0.420	+2.662	.002	<.001	3	1
UCEC	Notch1 →	+0.156	+2.169	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

FoxM1 by SPARC expression — UCEC

Explore this box plot interactively →