SPARC

Across TCGA cell cohorts, SPARC RNA expression is significantly associated with the go_rna of many other GO terms, with 5,534 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPARC-associated GO terms across cancer lineages are Semicircular canal morphogenesis, Semicircular canal development, and Regulation of intracellular transport. Each is linked with SPARC in more than 17 cancer types. Because this analysis shows association rather than direction, both SPARC-to-partner and partner-to-SPARC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Semicircular canal morphogenesis grouped by SPARC-low versus SPARC-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPARC→partner) and Y-score (partner→SPARC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Semicircular canal morphogenesis →	+1.912	+3.919	<.001	<.001	3	18
BLOOD_Myeloma	Semicircular canal development →	+1.912	+3.919	<.001	<.001	3	18
BREAST	Regulation of intracellular transport →	+0.057	+4.710	<.001	<.001	3	14
BONE	Regulation of focal adhesion assembly →	+0.220	+4.510	<.001	<.001	3	13
BONE	Regulation of cell-substrate junction assembly →	+0.220	+4.510	<.001	<.001	3	13
BONE	Negative regulation of Rho protein signal transduction →	+0.167	+3.233	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,534 associations by consensus.

Semicircular canal morphogenesis by SPARC expression — BLOOD_Myeloma

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