Across TCGA pan-cancer cohorts, SPANXN4 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated SPANXN4 data layer compared with 10 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher SPANXN4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPANXN4 expression acts as an unfavorable survival marker.

SCLC are the cancer types where SPANXN4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.055	0.708	<.001	36	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: SPANXN4 tumor-vs-normal RNA expression · all SPANXN4 data types