Across TCGA pan-cancer cohorts, SPANXN1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SPANXN1 data layer compared with 17 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SPANXN1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPANXN1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UVM, UCEC, and DLBC are the cancer types where SPANXN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.136	0.919	<.001	30	view →
UCEC	DFS	Median	All	1.000	0.628	.023	16	view →
DLBC	OS	Median	All	0.054	0.842	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SPANXN1 tumor-vs-normal RNA expression · all SPANXN1 data types