Across TCGA patient cohorts, SPANXN1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPANXN1-associated genes across cancer lineages are 4E-BP1, A-Raf_pS299, and ACVRL1. Each is linked with SPANXN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPANXN1-to-partner and partner-to-SPANXN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPANXN1→partner) and Y-score (partner→SPANXN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.370	+3.029	.003	.018	3	2
UCEC	A-Raf_pS299 →	-0.145	-2.321	.009	.034	3	1
UCEC	ACVRL1 →	-0.136	-2.986	.032	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.176	-3.000	.024	.036	3	1
UCEC	Notch1 →	+0.254	+1.750	<.001	.049	3	1
UCEC	Annexin-1 →	+0.596	+2.189	.015	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

SPANXN1 survival (RNA) · tumor vs normal (RNA) · all SPANXN1 data types