Across TCGA patient cohorts, SPANXD mutation is significantly associated with the RNA expression of many other genes, with 1,662 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPANXD-associated genes across cancer lineages are TOMM5, DEAF1, and MRPL22. Each is linked with SPANXD in more than 1 cancer types. Because this analysis shows association rather than direction, both SPANXD-to-partner and partner-to-SPANXD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPANXD→partner) and Y-score (partner→SPANXD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TOMM5 →	+0.696	+3.491	<.001	.002	3	2
SKCM	DEAF1 →	+0.529	+3.019	.006	<.001	3	2
UCEC	MRPL22 →	+0.426	+3.525	<.001	.002	3	2
COAD	LINC01817 →	+0.089	+3.707	<.001	.002	3	2
UCEC	URGCP-MRPS24 →	+0.310	+2.747	<.001	.001	3	2
COAD	RBAK-RBAKDN →	+0.224	+3.483	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,662 associations by consensus.

Exploration

SPANXD survival (RNA) · tumor vs normal (RNA) · all SPANXD data types