Across TCGA patient cohorts, SPANXD mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPANXD-associated genes across cancer lineages are ATM, Caspase-8, and eEF2. Each is linked with SPANXD in more than 1 cancer types. Because this analysis shows association rather than direction, both SPANXD-to-partner and partner-to-SPANXD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPANXD→partner) and Y-score (partner→SPANXD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.850	-3.308	<.001	.009	3	2
UCEC	Caspase-8 →	-0.303	-3.432	.009	.005	3	2
UCEC	eEF2 →	+0.413	+2.584	.013	.011	3	1
UCEC	EGFR_pY1068 →	-0.305	-3.700	.009	.001	3	1
UCEC	ERK2 →	+0.245	+2.999	.006	.035	3	1
UCEC	GAPDH →	+0.681	+3.321	.006	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

SPANXD survival (RNA) · tumor vs normal (RNA) · all SPANXD data types