SPAG7

Across TCGA pan-cancer cohorts, SPAG7 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SPAG7 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SPAG7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPAG7 expression acts as an unfavorable survival marker.

KIRP, COAD, and ACC are the cancer types where SPAG7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.152	0.695	<.001	37	view →
COAD	OS	Median	All	0.391	0.871	<.001	24	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SPAG7–KIRP (OS)

Open the KIRP breakdown →