SPAG7

Across TCGA pan-cancer cohorts, SPAG7 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SPAG7 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SPAG7 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SPAG7 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where SPAG7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.828	0.428	.002	64	view →
PDAC	DFS	Tertile	All	0.561	0.319	.001	51	view →
HNSC	DFS	Quartile	II,III,IV	0.670	0.958	<.001	41	view →
LSCC	OS	Median	All	1.000	0.813	.037	2	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.884	.020	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SPAG7–CCRCC (DFS)

Open the CCRCC breakdown →