SPAG7

Across TCGA pan-cancer cohorts, SPAG7 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SPAG7’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where SPAG7 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SPAG7 is over-expressed in tumor, although a few such as PDAC and CCRCC show the opposite, repressed pattern.

PDAC, LSCC, and CCRCC are the cancer types where SPAG7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPAG7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	III,IV	−0.762	<.001	9	view →
LSCC	Male	All	+0.178	<.001	4	view →
CCRCC	Female	IV	−0.338	.040	1	view →
LUAD	All	All	+0.071	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SPAG7–PDAC

Open the PDAC breakdown →