SPAG5

Across TCGA pan-cancer cohorts, SPAG5 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SPAG5’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SPAG5 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SPAG5 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LUAD, LSCC, and HNSC are the cancer types where SPAG5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPAG5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+1.489	<.001	9	view →
LSCC	Male	III,IV	+0.786	<.001	8	view →
HNSC	Male	III,IV	+0.456	<.001	8	view →
PDAC	Male	All	−0.465	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SPAG5–LUAD

Open the LUAD breakdown →